humanized glp-1 receptor knock-in mouse Reagents and models for detecting endogenous GLP1R and GIPR A Novel Humanized GLP-1 Receptor

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(12) The potential actions of ipamorelin on bone cells and tissues in these controlled murine research models include increased deposition of mineral content and expanded cortical bone cross-sectional area, but seemingly not through altering the inherent mineral concentration of the bone matrix itself

Although the exact mechanisms by which the coordinated actions of GLP-1 receptor agonism and NMDA receptor antagonism correct metabolic diseases await further elucidation, the extensive alterations in transcriptomic and proteomic responses within the hypothalamus, linked to glutamatergic signalling and synaptic plasticity, imply that the conjugate might elicit neurostructural changes in GLP-1-receptor-expressing neurons

10.3390/cancers16050880 108 JiaD.TianZ.WangR